TCM-Suite
A comprehensive and holistic platform for
TCM composition identification(Holmes-Suite) and network pharmacology analysis(Watson-Suite)
Formula
Example Formula:
Hu Gan Pills护肝丸
TCMSuiteINTRODUCTION
TCM-Suite database is developed to combine Traditional Chinese Medicine (TCM) identification with downstream network pharmacology investigation into a holistic platform. In TCM-Suite, two sub-databases namely Holmes-Suite and Watson-Suite are constructed for TCM identification and network pharmacology investigation, respectively, both AI enabled. TCM-Suite could facilitate clinical applications and drug development based on TCM.
POWERFUL
DATABASE
0
Mark Gene Number
in Holmes
0
Network Pharmacology Entries
in Watson
Formula:6,692
Herb:7,322
Compound:704,321
Protein:19,319
Disease:15,437
Holmes-Suite
A standardized short sequence of DNA from a small region of an organism's genome that can differentiate the species from others.
For plants, the chosen and validated sequences include ITS2, matK, tml, trnH-psbA etc. for the identification of plant species.
Identified TCM ingredient by marker gene
TCM ingredient retrieved by phamacopeia
Watson-Suite
Watson-Suite is designed as an integration of database and a datamining system for network pharmacology analysis of TCM preparations. We have collected information on all respects of TCM including herbs, herbal ingredients, targets, related disease, side effect and toxicity
A Holistic Pipeline to Combine TCM Composition Identification
and Network Pharmacology Analysis
Step 01
Nucleotide Sequencing for TCM
> Bos taurus
CAGCAACTTGCTC
Step 02
Composition identification for TCM
( Holmes-Suite )
Step 03
Herb information investigation
( Watson-Suite )
Step 06
Protein/gene-related disease
( Watson-Suite )
Step 05
Compounds-related protein/gene
( Watson-Suite )
Step 04
Herb-related compounds
( Watson-Suite )
HOW TO CITE
Pengshuo Yang, Jidong Lang, Hongjun Li, Jinxiang Lu, Hanyang Lin, Geng Tian, Hong Bai, Jialiang Yang, and Kang Ning. 2022. “ TCM-Suite: A comprehensive and holistic platform for Traditional Chinese Medicine component identification and network pharmacology analysis.” iMeta. e47. https://doi.org/10.1002/imt2.47 |
PUBLICATIONS
| 1. | Runzhi Zhang1,Gao Xi1, Hong Bai*, Kang Ning*. Traditional Chinese Medicine and gut microbiome: Their respective and concert effects on healthcare. Frontiers in Pharmacology, 2020;11:538. |
| 2. | Hong Bai, Xianhong Li, Hongjun Li, Jialiang Yang, Kang Ning*. Biological ingredient complement chemical ingredient in assessment of quality of TCM preparations. Scientific Reports, 2019 Apr 10;9(1):5853. |
| 3. | Runzhi Zhang, Xue Zhu, Hong Bai*, Kang Ning*. Network pharmacology Databases for Traditional Chinese Medicine: Review and Assessment. Frontiers in Pharmacology, 2019 Feb 21;10:123. |
| 4. | Run-zhi Zhang, Shao-jun Yu, Hong Bai*, Kang Ning*. TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations. Sientific reports, 2017 Jun 6;7(1):2821. |