TCM Suite

TCMSuite

TCM-Suite

A comprehensive and holistic platform for

TCM composition identification(Holmes-Suite) and network pharmacology analysis(Watson-Suite)

Example Formula:

Hu Gan Pills护肝丸

INTRODUCTION

TCM-Suite database is developed to combine Traditional Chinese Medicine (TCM) identification with downstream network pharmacology investigation into a holistic platform. In TCM-Suite, two sub-databases namely Holmes-Suite and Watson-Suite are constructed for TCM identification and network pharmacology investigation, respectively, both AI enabled. TCM-Suite could facilitate clinical applications and drug development based on TCM.

POWERFUL

DATABASE

Mark Gene Number

in Holmes

Network Pharmacology Entries

in Watson

Formula:6,692

Herb:7,322

Compound:704,321

Protein:19,319

Disease:15,437

Holmes-Suite

A standardized short sequence of DNA from a small region of an organism's genome that can differentiate the species from others.

For plants, the chosen and validated sequences include ITS2, matK, tml, trnH-psbA etc. for the identification of plant species.

Identified TCM ingredient by marker gene

TCM ingredient retrieved by phamacopeia

Watson-Suite

Watson-Suite is designed as an integration of database and a datamining system for network pharmacology analysis of TCM preparations. We have collected information on all respects of TCM including herbs, herbal ingredients, targets, related disease, side effect and toxicity

A Holistic Pipeline to Combine TCM Composition Identification

and Network Pharmacology Analysis

Step 01

Nucleotide Sequencing for TCM

> Bos taurus

CAGCAACTTGCTC

Step 02

Composition identification for TCM

( Holmes-Suite )

Step 03

Herb information investigation

( Watson-Suite )

Step 06

Protein/gene-related disease

( Watson-Suite )

Step 05

Compounds-related protein/gene

( Watson-Suite )

Step 04

Herb-related compounds

( Watson-Suite )

PUBLICATIONS

1.	Runzhi Zhang¹,Gao Xi¹, Hong Bai^, Kang Ning^. Traditional Chinese Medicine and gut microbiome: Their respective and concert effects on healthcare. Frontiers in Pharmacology, 2020;11:538.
2.	Hong Bai, Xianhong Li, Hongjun Li, Jialiang Yang, Kang Ning^*. Biological ingredient complement chemical ingredient in assessment of quality of TCM preparations. Scientific Reports, 2019 Apr 10;9(1):5853.
3.	Runzhi Zhang, Xue Zhu, Hong Bai^, Kang Ning^. Network pharmacology Databases for Traditional Chinese Medicine: Review and Assessment. Frontiers in Pharmacology, 2019 Feb 21;10:123.
4.	Run-zhi Zhang, Shao-jun Yu, Hong Bai^, Kang Ning^. TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations. Sientific reports, 2017 Jun 6;7(1):2821.